作者
Ludwig Dubois, Sarah Peeters, Natasja G Lieuwes, Nele Geusens, Anne Thiry, Simon Wigfield, Fabrizio Carta, Alan Mcintyre, Andrea Scozzafava, Jean-Michel Dogné, Claudiu T Supuran, Adrian L Harris, Bernard Masereel, Philippe Lambin
发表日期
2011/6/1
期刊
Radiotherapy and Oncology
卷号
99
期号
3
页码范围
424-431
出版商
Elsevier
简介
BACKGROUND AND PURPOSE
Carbonic anhydrase (CA) IX expression is increased upon hypoxia and has been proposed as a therapeutic target since it has been associated with poor prognosis, tumor progression and pH regulation. The aim of this study was to evaluate the antitumor activity of a high CAIX-affinity indanesulfonamide (11c) combined with irradiation, compared with the general CA inhibitor acetazolamide (AZA).
MATERIAL AND METHODS
HT-29 carcinoma cells with or without (genetic knockdown, KD) CAIX expression were incubated with 11c/AZA under different oxygen levels and proliferation, apoptosis and radiosensitivity were evaluated. 11c/AZA was administered intravenously (1×/day; 5days) to tumor-bearing mice and tumor irradiation (10Gy) was performed at day 3 of the injection period. Tumor growth and potential treatment toxicity were monitored (3×/week).
RESULTS
Treatment with …
学术搜索中的文章
L Dubois, S Peeters, NG Lieuwes, N Geusens, A Thiry… - Radiotherapy and Oncology, 2011