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Results

At cohort entry, the mean age was 54.8 years (SD 13.3), 56.5% were men, and 72.8% were black. The prevalence of frailty and intermediate frailty were 34.0% and 37.7%, respectively. The mean 3MS was 89.8 (SD 7.6), TMTA was 55.4 (SD 29), and TMTB was 161 (SD 83). Frailty was independently associated with lower cognitive function at cohort entry for all three measures (3MS:− 2.4 points; 95% confidence interval [95% CI],− 4.2 to− 0.5; P= 0.01; TMTA: 12.1 seconds; 95% CI, 4.7 to 19.4; P< 0.001; and TMTB: 33.2 seconds; 95% CI, 9.9 to 56.4; P= 0.01; all tests for trend, P< 0.001) and with worse 3MS at 1-year follow-up (− 2.8 points; 95% CI,− 5.4 to− 0.2; P= 0.03).

Conclusions

In adult incident HD patients, frailty is associated with worse cognitive function, particularly global cognitive function (3MS).