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In this study, closed CO₂ cycles are investigated for potential application in existing nuclear power stations, referring in particular to Mochovce power station currently under construction in Slovak Republic. Three different CO₂ cycles layouts are explored in the range of temperatures offered by the nuclear source and of the existing cooling towers. The investigation shows that the common opinion that S-CO₂ cycles are well suited in the medium to a high temperature range only (higher than about 450 °C) seems unjustified. For a primary heat source with a maximum temperature of 299 °C and a heat sink with a minimum temperature of 19 °C and reasonable assumptions about advanced turbomachines and heat exchanger performances, the supercritical recompressed reheated regenerative CO₂ cycle would yield a net efficiency of 34.04%, which compares well with the 33.51% net efficiency of the existing Rankine …