作者
Jessica L Petrick, Jake E Thistle, Anne Zeleniuch-Jacquotte, Xuehong Zhang, Jean Wactawski-Wende, Alison L Van Dyke, Meir J Stampfer, Rashmi Sinha, Howard D Sesso, Catherine Schairer, Lynn Rosenberg, Thomas E Rohan, Kim Robien, Mark P Purdue, Jenny N Poynter, Julie R Palmer, Christina C Newton, Martha S Linet, Linda M Liao, I-Min Lee, Jill Koshiol, Cari M Kitahara, Jonathan N Hofmann, Barry I Graubard, Edward Giovannucci, Michael J Gaziano, Susan M Gapstur, Neal D Freedman, Dawn Q Chong, Andrew T Chan, Julie E Buring, Laura Beane E Freeman, Peter T Campbell, Katherine A McGlynn
发表日期
2018/10/1
来源
Official journal of the American College of Gastroenterology| ACG
卷号
113
期号
10
页码范围
1494-1505
出版商
LWW
简介
OBJECTIVE:
Obesity and diabetes are associated with an increased liver cancer risk. However, most studies have examined all primary liver cancers or hepatocellular carcinoma, with few studies evaluating intrahepatic cholangiocarcinoma (ICC), the second most common type of liver cancer. Thus, we examined the association between obesity and diabetes and ICC risk in a pooled analysis and conducted a systematic review/meta-analysis of the literature.
DESIGN:
For the pooled analysis, we utilized the Liver Cancer Pooling Project, a consortium of 13 US-based, prospective cohort studies with data from 1,541,143 individuals (ICC casesn= 414). In our systematic review, we identified 14 additional studies. We then conducted a meta-analysis, combining the results from LCPP with results from the 5 prospective studies identified through September 2017.
RESULTS:
In the LCPP, obesity and diabetes were associated …
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