作者
Jundan Huang, Xianmei Zeng, Mingyue Hu, Hongting Ning, Shuang Wu, Ruotong Peng, Hui Feng
发表日期
2023
来源
Frontiers in Aging Neuroscience
卷号
15
出版商
Frontiers Media SA
简介
Background
Several prediction models for cognitive frailty (CF) in older adults have been developed. However, the existing models have varied in predictors and performances, and the methodological quality still needs to be determined.
Objectives
We aimed to summarize and critically appraise the reported multivariable prediction models in older adults with CF.
Methods
PubMed, Embase, Cochrane Library, Web of Science, Scopus, PsycINFO, CINAHL, China National Knowledge Infrastructure, and Wanfang Databases were searched from the inception to March 1, 2022. Included models were descriptively summarized and critically appraised by the Prediction Model Risk of Bias Assessment Tool (PROBAST).
Results
A total of 1,535 articles were screened, of which seven were included in the review, describing the development of eight models. Most models were developed in China (n = 4, 50.0%). The most common predictors were age (n = 8, 100%) and depression (n = 4, 50.0%). Seven models reported discrimination by the C-index or area under the receiver operating curve (AUC) ranging from 0.71 to 0.97, and four models reported the calibration using the Hosmer–Lemeshow test and calibration plot. All models were rated as high risk of bias. Two models were validated externally.
Conclusion
There are a few prediction models for CF. As a result of methodological shortcomings, incomplete presentation, and lack of external validation, the models’ usefulness still needs to be determined. In the future, models with better prediction performance and methodological quality should be developed and validated externally.
Systematic review …
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