作者
Jessica Cannavino, Lorenza Brocca, Marco Sandri, Bruno Grassi, Roberto Bottinelli, Maria Antonietta Pellegrino
发表日期
2015/4/15
期刊
The Journal of physiology
卷号
593
期号
8
页码范围
1981-1995
简介
Key points
- Skeletal muscle atrophy occurs as a result of disuse. Although several studies have established that a decrease in protein synthesis and increase in protein degradation lead to muscle atrophy, little is known about the triggers underlying such processes.
- A growing body of evidence challenges oxidative stress as a trigger of disuse atrophy; furthermore, it is also becoming evident that mitochondrial dysfunction may play a causative role in determining muscle atrophy.
- Mitochondrial fusion and fission have emerged as important processes that govern mitochondrial function and PGC‐1α may regulate fusion/fission events.
- Although most studies on mice have focused on the anti‐gravitary slow soleus muscle as it is preferentially affected by disuse atrophy, several fast muscles (including gastrocnemius) go through a significant loss of mass following unloading.
- Here we found that in fast muscles an early …
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J Cannavino, L Brocca, M Sandri, B Grassi, R Bottinelli… - The Journal of physiology, 2015