作者
Lorenza Brocca, Luana Toniolo, Carlo Reggiani, Roberto Bottinelli, Marco Sandri, Maria Antonietta Pellegrino
发表日期
2017/2/15
期刊
The Journal of physiology
卷号
595
期号
4
页码范围
1143-1158
简介
Key points
- Muscle atrophy is a debilitating condition that affects a high percentage of the population with a negative impact on quality of life.
- Dissecting the molecular level of the atrophy process, and the similarities/dissimilarities among different catabolic conditions, is a necessary step for designing specific countermeasures to attenuate/prevent muscle loss.
- The FoxO family transcription factors represent one of the most important regulators of atrophy programme stimulating the expression of many atrophy‐related genes.
- The findings of the present study clearly indicate that the signalling network controlling the atrophy programme is specific for each catabolic condition.
Abstract
Muscle atrophy is a complex process that is in common with many different catabolic diseases including disuse/inactivity and ageing. The signalling pathways that control the atrophy programme in the different disuse/inactivity conditions …
学术搜索中的文章
L Brocca, L Toniolo, C Reggiani, R Bottinelli, M Sandri… - The Journal of physiology, 2017