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MATERIALS AND METHODS

This study was conducted in the Department of Hematology, Trakya University Medical Faculty; 21 lym phoma, 14 multiple myeloma (MM), 14 acute leukemia, and 13 chronic lymhocytic leukemia (CLL) patients were included into the study. The control group composed of 25 healthy subjects within the same age range. Of lymphoma patients, 11 had Hodgkin lymphoma (HL) and 10 had nonHodgkin lymphoma (NHL). Of leukemia pa tients, 11 had acute nonlymphoblastic leukemia (ANLL) and 3 had acute lymphoblastic leukemia (ALL). Patients were either initially diagnosed or they were relapsed patients. All patients were off treatment for at least 3 months. Patients with documented infection within the last 2 weeks; those with febrile neutropenia, sepsis, any organ failure (kidney, liver, lung, heart); patients with hypertension or diabetes were excluded. All CLL patients fulfilled CLL diagnostic criteria defined by the International Workshop on CLL [10]. The diagno ses of HL and NHL were based on the histopathologic examination of a lymph node or extranodal tissue biopsy specimen. All CLL patients were classified into stages according to the system of Rai et al.[11]. Lymphoma patients were staged clinically according to AnnArbor classification [12]. MM patients were classified according to DurieSalmon staging system [13]. CLL patients with