作者
V Giannini, S Mazzetti, I Bertotto, C Chiarenza, S Cauda, E Delmastro, C Bracco, A Di Dia, F Leone, E Medico, A Pisacane, D Ribero, M Stasi, D Regge
发表日期
2019/4/1
期刊
European journal of nuclear medicine and molecular imaging
卷号
46
页码范围
878-888
出版商
Springer Berlin Heidelberg
简介
Purpose
Pathological complete response (pCR) following neoadjuvant chemoradiotherapy or radiotherapy in locally advanced rectal cancer (LARC) is reached in approximately 15–30% of cases, therefore it would be useful to assess if pretreatment of 18F-FDG PET/CT and/or MRI texture features can reliably predict response to neoadjuvant therapy in LARC.
Methods
Fifty-two patients were dichotomized as responder (pR+) or non-responder (pR-) according to their pathological tumor regression grade (TRG) as follows: 22 as pR+ (nine with TRG = 1, 13 with TRG = 2) and 30 as pR- (16 with TRG = 3, 13 with TRG = 4 and 1 with TRG = 5). First-order parameters and 21 second-order texture parameters derived from the Gray-Level Co-Occurrence matrix were extracted from semi-automatically segmented tumors on T2w MRI, ADC maps, and PET …
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V Giannini, S Mazzetti, I Bertotto, C Chiarenza… - European journal of nuclear medicine and molecular …, 2019