作者
Ulrich Duffner, Bao Lu, Gerhard C Hildebrandt, Takanori Teshima, Debra L Williams, Pavan Reddy, Rainer Ordemann, Shawn G Clouthier, Kathy Lowler, Chen Liu, Craig Gerard, Kenneth R Cooke, James LM Ferrara
发表日期
2003/10/1
期刊
Experimental hematology
卷号
31
期号
10
页码范围
897-902
出版商
Elsevier
简介
OBJECTIVE
The chemokine receptor CXCR3 has an important role in the migration of effector T cells. To investigate the role of CXCR3 on donor cells in acute graft vs host disease (GVHD) we used a well-defined experimental bone marrow transplantation (BMT) model where acute GVHD is mediated by donor CD8+ T cells against minor histocompatibility antigens.
METHODS
Lethally irradiated C3H.SW recipients were transplanted from either wild-type B6 or CXCR3−/− B6 donors. Donor T-cell expansion was analyzed in the spleen and small intestine of recipients by FACS. Donor T-cell function was analyzed by cytokine secretion. The severity of acute GVHD was assessed by histopathological analysis of intestine and liver, GVHD clinical scores, and survival after BMT.
RESULTS
Significantly higher numbers of donor CD8+ CXCR3−/− T cells were found in the spleen on days +7 and +14 compared to donor wild …
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U Duffner, B Lu, GC Hildebrandt, T Teshima… - Experimental hematology, 2003