作者
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W Siegel, Jinbiao Chen, Beverly A Heinz, Richard E Higgs, Nicole L Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A Smith, David W Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A Garces, Courtney A Cohen, John M Dye, Kathleen E Huie, Catherine V Badger, Darwyn Kobasa, Jonathan Audet, Joshua J Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C Palma, Bharathi Ramamurthy, Robert W Cross, Thomas W Geisbert, Vineet Menachery, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D Kwong, Nancy J Sullivan, Barney S Graham, Tara L Fernandez, Carl L Hansen, Ester Falconer, John R Mascola, Bryan E Jones, Bryan C Barnhart
发表日期
2022/5/17
期刊
Cell reports
卷号
39
期号
7
出版商
Elsevier
简介
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of concern (VOCs) have negatively affected therapeutic use of some authorized mAbs. Using a high-throughput B cell screening pipeline, we isolated LY-CoV1404 (bebtelovimab), a highly potent SARS-CoV-2 spike glycoprotein receptor binding domain (RBD)-specific antibody. LY-CoV1404 potently neutralizes authentic SARS-CoV-2, B.1.1.7, B.1.351, and B.1.617.2. In pseudovirus neutralization studies, LY-CoV1404 potently neutralizes variants, including B.1.1.7, B.1.351, B.1.617.2, B.1.427/B.1.429, P.1, B.1.526, B.1.1.529, and the BA.2 subvariant. Structural analysis reveals that the contact residues of the LY-CoV1404 epitope are highly conserved, except for N439 …
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K Westendorf, S Žentelis, L Wang, D Foster… - Cell reports, 2022