作者
Giulio Cavalli, Giacomo De Luca, Corrado Campochiaro, Emanuel Della-Torre, Marco Ripa, Diana Canetti, Chiara Oltolini, Barbara Castiglioni, Chiara Tassan Din, Nicola Boffini, Alessandro Tomelleri, Nicola Farina, Annalisa Ruggeri, Patrizia Rovere-Querini, Giuseppe Di Lucca, Sabina Martinenghi, Raffaella Scotti, Moreno Tresoldi, Fabio Ciceri, Giovanni Landoni, Alberto Zangrillo, Paolo Scarpellini, Lorenzo Dagna
发表日期
2020/6/1
期刊
The Lancet Rheumatology
卷号
2
期号
6
页码范围
e325-e331
出版商
Elsevier
简介
Background
Mortality of patients with coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARDS), and systemic inflammation is high. In areas of pandemic outbreak, the number of patients can exceed maximum capacity of intensive care units (ICUs), and, thus, these individuals often receive non-invasive ventilation outside of the ICU. Effective treatments for this population are needed urgently. Anakinra is a recombinant interleukin-1 receptor antagonist that might be beneficial in this patient population.
Methods
We conducted a retrospective cohort study at the San Raffaele Hospital in Milan, Italy. We included consecutive patients (aged ≥18 years) with COVID-19, moderate-to-severe ARDS, and hyperinflammation (defined as serum C-reactive protein ≥100 mg/L, ferritin ≥900 ng/mL, or both) who were managed with non-invasive ventilation outside of the ICU and who received standard …
学术搜索中的文章
G Cavalli, G De Luca, C Campochiaro, E Della-Torre… - The Lancet Rheumatology, 2020