作者
Olga Rodríguez-Núñez, Marco Ripa, Laura Morata, Cristina de la Calle, Celia Cardozo, Csaba Fehér, Martina Pellicé, Andrea Valcarcel, Pedro Puerta-Alcalde, Francesc Marco, Carolina Garcia-Vidal, Ana del Río, Alex Soriano, Jose Antonio Martínez-Martínez
发表日期
2018/12/1
期刊
Journal of global antimicrobial resistance
卷号
15
页码范围
136-139
出版商
Elsevier
简介
Objectives
The steady progress in resistance of Pseudomonas aeruginosa (PA) has led to difficulties in treating infections due to multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Ceftazidime/avibactam (CAZ/AVI) has in vitro activity against many of these strains, however clinical experience with CAZ/AVI is limited. This study aimed to evaluate the characteristics and outcomes of eight patients with infections due to MDR- or XDR-PA treated with CAZ/AVI, including four strains resistant to ceftolozane/tazobactam.
Methods
This was a retrospective descriptive study of patients admitted to a teaching hospital between January 2016 and May 2017 who received CAZ/AVI as initial or continuation therapy for infection due to MDR- and XDR-PA.
Results
The sources of infection were hospital-acquired lower respiratory tract infection in five patients (62.5%) and osteomyelitis, meningitis and catheter-related …
学术搜索中的文章
O Rodríguez-Núñez, M Ripa, L Morata, C de la Calle… - Journal of global antimicrobial resistance, 2018