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Deployment of autonomous vehicles (AVs) may hold health and safety benefits for drivers with and without disabilities across the adult lifespan. While transportation is critical in helping people with disabilities (PWDs) access health care, services, jobs, goods, community involvement, and societal participation, the current transportation system has not provided ubiquitous accessible, affordable, available, acceptable, and adaptable (the 5As) transportation to this group. The anticipated integration of automated shared mobility services into our transportation system—including the autonomous shuttle (AS)— renews cities’ and states’ opportunity to further enhance PWDs’ quality of life. The current project (STRIDE A5) had two objectives: (1) Quantify and qualify PWDs’ (N=42) perceptions, values, beliefs, and attitudes before and after riding in an AS (Level 4, SAE Guidelines); and (2) Build a model of facilitators and barriers of AS from data collected in STRIDE D2 (Phase 1; older drivers, N=50), STRIDE A3 (Phase 2; younger and middle-aged drivers, N=51), and this project (PWDs, N=42).The study included adults across the lifespan with and without disabilities. The findings reveal important foundational information about driver Acceptance of AVs, Intention to Use AVs, Perceived Barriers to AV technology, and Well-being related to AV technology use. Qualitatively, and among those without and with disabilities, seven themes emerged to highlight the importance of Safety, Ease of Use, Cost (affordability), Availability, Disability (for the PWDs), Information about AVs, and prior or future Experience with AVs. Compared to the other groups, PWDs’ main …