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The accuracy of clinical diagnosis of Parkinson disease is currently not satisfying, particularly in early Parkinson disease where clinical signs are not yet fully present. Imaging nigral structures has been proposed as a biomarker for PD but fails to provide effective differential diagnosis. In this study we compared motor brain regions between hemispheres in patients with asymmetrical motor symptoms using voxel based analysis and network analysis and have found significant regional differences between the more and less affected hemispheres as well as connectivity differences in frontal and cerebral regions as the main hubs.