作者
Travis T Mallard, Jeanne E Savage, Emma C Johnson, Yuye Huang, Alexis C Edwards, Jouke J Hottenga, Andrew D Grotzinger, Daniel E Gustavson, Mariela V Jennings, Andrey Anokhin, Danielle M Dick, Howard J Edenberg, John R Kramer, Dongbing Lai, Jacquelyn L Meyers, Ashwini K Pandey, Kathryn Paige Harden, Michel G Nivard, Eco JC de Geus, Dorret I Boomsma, Arpana Agrawal, Lea K Davis, Toni-Kim Clarke, Abraham A Palmer, Sandra Sanchez-Roige
发表日期
2022/1
期刊
American Journal of Psychiatry
卷号
179
期号
1
页码范围
58-70
出版商
American Psychiatric Association
简介
Objective
Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be influenced by numerous biases (e.g., measurement error, selection bias), which may have led to inconsistent genetic correlations between alcohol involvement and AUD, as well as paradoxically negative genetic correlations between alcohol involvement and psychiatric disorders and/or medical conditions. The authors used genomic structural equation modeling to elucidate the genetics of alcohol consumption and problematic consequences of alcohol use as measured by AUDIT.
Methods
To explore these unexpected differences in genetic correlations, the authors conducted the first item-level and the largest GWAS of AUDIT items …
学术搜索中的文章
TT Mallard, JE Savage, EC Johnson, Y Huang… - American Journal of Psychiatry, 2022