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The healthcare industry is significantly impacted by the next generation of internet of things (NGIoT), particularly in terms of digital connectivity infrastructures. This chapter of the book examines the role that cutting-edge technology and human-centered techniques are playing in the development of NGIoT in healthcare. The subjects addressed include digital connection infrastructures including interoperability, communication protocols, privacy, and security, as well as sensor technologies, edge computing, artificial intelligence, blockchain, and cloud computing. The chapter focuses on user-centric design concepts, user experience, ethical considerations, and stakeholder involvement to emphasise the need of a human-centered approach. In this chapter, case studies and best practises for adopting the NGIoT are described along with lessons learned and challenges faced. The chapter summarises the key …