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In this letter we purpose adaptive neuro-fuzzy inference system (ANFIS) for channel estimation in orthogonal frequency division multiplexing (OFDM) systems. To evaluate the performance of this estimator, we compare the ANFIS with least square (LS) algorithm, minimum mean square error (MMSE) algorithm by using bit error rate (BER) and mean square error (MSE) criterias. According to computer simulations the performance of ANFIS has better performance than LS algorithm and close to MMSE algorithm. Besides there is unnecessity to send pilot when used the ANFIS.