作者
C-K Peng, Sergey V Buldyrev, Shlomo Havlin, Michael Simons, H Eugene Stanley, Ary L Goldberger
发表日期
1994/2/1
期刊
Physical Review E
卷号
49
期号
2
页码范围
1685
出版商
American Physical Society
简介
Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure (‘‘patchiness’’) of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms—one without and one with long-range power-law correlations. Although both types of sequences are highly heterogeneous, they are quantitatively distinguishable by new fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties.
引用总数
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