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To assess the relative risks (RR) of microbial keratitis (MK) for contemporary contact lens (CL) types and wearing schedules.

A 2-year prospective case-control study begun in December 2003.

Cases were 367 CL wearers attending Moorfields Eye Hospital with proven or presumed MK. Controls were 1069 hospital controls, who were CL wearers with a disorder unrelated to CL wear, and 639 population-based controls who were CL wearers randomly selected from the Moorfields catchment area. Hospital patients completed a self-administered questionnaire; population-based controls were interviewed by telephone.

Multivariate analysis was done both for all cases of MK, and for the moderate and severe MK subgroups alone.

The RR for developing MK, and vision loss, for all lens types compared with planned replacement soft lenses …