作者
Ynte Biemans, Daimy Bach, Pariya Behrouzi, Steve Horvath, Charlotte S Kramer, Simin Liu, JoAnn E Manson, Aladdin H Shadyab, James Stewart, Eric A Whitsel, Bo Yang, Lisette de Groot, Pol Grootswagers
发表日期
2024/5
期刊
Age and ageing
卷号
53
期号
Supplement_2
页码范围
ii20-ii29
出版商
Oxford University Press
简介
Background
Heterogeneity in ageing rates drives the need for research into lifestyle secrets of successful agers. Biological age, predicted by epigenetic clocks, has been shown to be a more reliable measure of ageing than chronological age. Dietary habits are known to affect the ageing process. However, much remains to be learnt about specific dietary habits that may directly affect the biological process of ageing.
Objective
To identify food groups that are directly related to biological ageing, using Copula Graphical Models.
Methods
We performed a preregistered analysis of 3,990 postmenopausal women from the Women’s Health Initiative, based in North America. Biological age acceleration was calculated by the epigenetic clock PhenoAge using whole-blood DNA methylation. Copula Graphical Modelling, a powerful data-driven exploratory tool, was …
引用总数
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