作者
Philip C Robinson, Theodora AM Claushuis, Adrian Cortes, Tammy M Martin, David M Evans, Paul Leo, Pamela Mukhopadhyay, Linda A Bradbury, Katie Cremin, Jessica Harris, Walter P Maksymowych, Robert D Inman, Proton Rahman, Nigil Haroon, Lianne Gensler, Joseph E Powell, Irene E van der Horst‐Bruinsma, Alex W Hewitt, Jamie E Craig, Lyndell L Lim, Denis Wakefield, Peter McCluskey, Valentina Voigt, Peter Fleming, Spondyloarthritis Research Consortium of Canada, Australio-Anglo-American Spondylitis Consortium, International Genetics of Ankylosing Spondylitis Consortium, Wellcome Trust Case Control Study 2, Mariapia Degli‐Esposti, Jennifer J Pointon, Michael H Weisman, B Paul Wordsworth, John D Reveille, James T Rosenbaum, Matthew A Brown
发表日期
2015/1
期刊
Arthritis & rheumatology
卷号
67
期号
1
页码范围
140-151
简介
Objective
To use high‐density genotyping to investigate the genetic associations of acute anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS).
Methods
We genotyped samples from 1,711 patients with AAU (either primary or combined with AS), 2,339 AS patients without AAU, and 10,000 control subjects on an Illumina Immunochip Infinium microarray. We also used data for AS patients from previous genome‐wide association studies to investigate the AS risk locus ANTXR2 for its putative effect in AAU. ANTXR2 expression in mouse eyes was investigated by real‐time quantitative reverse transcription–polymerase chain reaction.
Results
A comparison between all patients with AAU and healthy control subjects showed strong association over HLA–B, corresponding to the HLA–B27 tag single‐nucleotide polymorphism rs116488202. The association of 3 non–major histocompatibility …
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