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Medical datasets are usually imbalanced, where negative cases severely outnumber positive cases. Therefore, it is essential to deal with this data skew problem when training machine learning algorithms. This study uses two representative lung cancer datasets, PLCO and NLST, with imbalance ratios (the proportion of samples in the majority class to those in the minority class) of 24.7 and 25.0, respectively, to predict lung cancer incidence. This research uses the performance of 23 class imbalance methods (resampling and hybrid systems) with three classical classifiers (logistic regression, random forest, and LinearSVC) to identify the best imbalance techniques suitable for medical datasets. Resampling includes ten under-sampling methods (RUS, etc.), seven over-sampling methods (SMOTE, etc.), and two integrated sampling methods (SMOTEENN, SMOTE-Tomek). Hybrid systems include (Balanced Bagging …