作者
Alexander Gusev, Pier Francesco Palamara, Gregory Aponte, Zhong Zhuang, Ariel Darvasi, Peter Gregersen, Itsik Pe'er
发表日期
2012/2/1
期刊
Molecular biology and evolution
卷号
29
期号
2
页码范围
473-486
出版商
Oxford University Press
简介
Homologous long segments along the genomes of close or remote relatives that are identical by descent (IBD) from a common ancestor provide clues for recent events in human genetics. We set out to extensively map such IBD segments in large cohorts and investigate their distribution within and across different populations. We report analysis of several data sets, demonstrating that IBD is more common than expected by naïve models of population genetics. We show that the frequency of IBD pairs is population dependent and can be used to cluster individuals into populations, detect a homogeneous subpopulation within a larger cohort, and infer bottleneck events in such a subpopulation. Specifically, we show that Ashkenazi Jewish individuals are all connected through transitive remote family ties evident by sharing of 50 cM IBD to a publicly available data set of less than 400 individuals. We further expose …
引用总数
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A Gusev, PF Palamara, G Aponte, Z Zhuang, A Darvasi… - Molecular biology and evolution, 2012