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In addition to being the primary organ involved in redox cycling, the liver is one of the most highly innervated tissues in mammals. The interaction between hepatocytes and sympathetic, parasympathetic, and peptidergic nerve fibers through a variety of neurotransmitters and signaling pathways is recognized as being important in the regulation of hepatocyte function, liver regeneration, and hepatic fibrosis. However, less is known regarding the role of the sympathetic nervous system (SNS) in modulating the hepatic response to oxidative stress. Our aim was to investigate the role of the SNS in healthy and oxidatively stressed liver parenchyma. Mice treated with 6‐hydroxydopamine hydrobromide were used to realize chemical sympathectomy. Carbon tetrachloride (CCl₄) injection was used to induce oxidative liver injury. Sympathectomized animals were protected from CCl₄ induced hepatic lipid peroxidation …