查看文章

Topical hemostatic agents are intended to stop the bleeding in patients with traumatic injury or during surgery. The existing drawbacks of current topical hemostats include its low efficiency, non-degradability, high cost and potential safety issues. In this study, we have attempted to develop a biocompatible, biodegradable hemostatic device by conjugating carboxymethyl moiety to starch (CM-starch) and further modifying it with calcium ions (CaCM-starch) to obtain free flowing microparticles with improved clotting efficiency. The hemostatic efficacy of the microparticles together with its biodegradable and biocompatible properties were evaluated using in-vitro and in-vivo studies. The results demonstrated that carboxymethyl modification of starch led to a substantial improvement in its fluid absorption and swelling properties due to improved hydrophilic property. Further modifications with calcium ions resulted in free …