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Classifying manual and non-manual gestures in sign language recognition is a complex and challenging task. Sign language gestures are the combination of hand, face, and body postures, which often have self-occlusions and inter-object occlusions of both the hands, hands with face, or hands with upper body postures. This paper addresses the characterization of manual and non-manual gestures in recognizing the sign language gestures from continuous video sequences. This paper introduces a novel hyperparameter based optimized Generative Adversarial Networks (H-GANs) to classify the sign gestures, and it works in three phases. In phase-I, it adapts the stacked variational auto-encoders (SVAE) and Principal Component Analysis (PCA) to get the pre-tuned data with reduced feature dimensions. In Phase-II, the H-GANs employed Deep Long Short Term Memory (LSTM) as generator and LSTM with 3D …