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We studied the influence of fly ash content and replacement of crushed sand stone aggregate with concrete wastes and marble wastes in pre-fabricated concrete interlocking blocks (PCIBs). We have compared properties of PCIBs with fly ash produced with three different replacement ratios of aggregate. Compressive strength, tensile splitting strength, density, apparent porosity, water absorption by weight, abrasion resistance, alkali-silica reaction and freeze–thaw resistance of PCIBs were determined. When comparing the PCIBs with crushed sand stone, the replacement of crushed sand stone with concrete waste and marble waste results in lower physical and mechanical properties. By contrast, replacement of cement with fly ash (from 10% to 20%) has a significant effect in increasing important properties of PCIBs.