作者
Matej Skorvanek, Pablo Martinez-Martin, Norbert Kovacs, Ivan Zezula, Mayela Rodriguez-Violante, Jean-Christophe Corvol, Pille Taba, Klaus Seppi, Oleg Levin, Anette Schrag, Iciar Aviles-Olmos, Mario Alvarez-Sanchez, Tomoko Arakaki, Zsuzsanna Aschermann, Eve Benchetrit, Charline Benoit, Alberto Bergareche-Yarza, Amin Cervantes-Arriaga, Anabel Chade, Florence Cormier, Veronika Datieva, David A Gallagher, Nelida Garretto, Zuzana Gdovinova, Oscar Gershanik, Milan Grofik, Vladimir Han, Liis Kadastik-Eerme, Monica M Kurtis, Graziella Mangone, Juan Carlos Martinez-Castrillo, Amelia Mendoza-Rodriguez, Michal Minar, Henry P Moore, Mari Muldmaa, Christoph Mueller, Bernadette Pinter, Werner Poewe, Karin Rallmann, Eva Reiter, Carmen Rodriguez-Blazquez, Carlos Singer, Peter Valkovic, Christopher G Goetz, Glenn T Stebbins
发表日期
2018/7/1
期刊
Parkinsonism & related disorders
卷号
52
页码范围
83-89
出版商
Elsevier
简介
Background
The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients.
Methods
We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items.
Results
A total of 3206 PD patients were included in the …
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M Skorvanek, P Martinez-Martin, N Kovacs, I Zezula… - Parkinsonism & related disorders, 2018