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Background: The minimal clinically important difference is the smallest change of scores clinically meaningful to patients.

Objectives: We aimed to calculate these threshold values in association with the International Parkinson and Movement Disorder Society UPDRS (MDS‐UPDRS) Parts I and II and to evaluate the feasibility of the composite score of Part I and II (MDS‐UPDRS I+II) as an outcome.

Methods: Nine hundred eighty‐five paired investigations of 365 patients were reviewed, implementing three different techniques simultaneously.

Results: Based on the ordinal regression modeling, the MDS‐UPDRS I+II score is an applicable outcome measure. Any improvement greater than 2.64 points or any worsening more than 2.45 points on MDS‐UPDRS Part I represent a minimal, yet clinically meaningful change. In reference to Part II, the smallest changes considered clinically relevant were 3.05 and 2.51 points …