作者
Betty Raman, Mark Philip Cassar, Elizabeth M Tunnicliffe, Nicola Filippini, Ludovica Griffanti, Fidel Alfaro-Almagro, Thomas Okell, Fintan Sheerin, Cheng Xie, Masliza Mahmod, Ferenc E Mózes, Adam J Lewandowski, Eric O Ohuma, David Holdsworth, Hanan Lamlum, Myles J Woodman, Catherine Krasopoulos, Rebecca Mills, Flora A Kennedy McConnell, Chaoyue Wang, Christoph Arthofer, Frederik J Lange, Jesper Andersson, Mark Jenkinson, Charalambos Antoniades, Keith M Channon, Mayooran Shanmuganathan, Vanessa M Ferreira, Stefan K Piechnik, Paul Klenerman, Christopher Brightling, Nick P Talbot, Nayia Petousi, Najib M Rahman, Ling-Pei Ho, Kate Saunders, John R Geddes, Paul J Harrison, Kyle Pattinson, Matthew J Rowland, Brian J Angus, Fergus Gleeson, Michael Pavlides, Ivan Koychev, Karla L Miller, Clare Mackay, Peter Jezzard, Stephen M Smith, Stefan Neubauer
发表日期
2021/1/1
期刊
EClinicalMedicine
卷号
31
出版商
Elsevier
简介
Background
The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood.
Methods
Fifty-eight COVID-19 patients post-hospital discharge and 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments.
Findings
At 2–3 months from disease-onset, 64% of patients experienced breathlessness and 55% reported fatigue. On MRI, abnormalities were seen in lungs (60%), heart (26%), liver (10%) and kidneys (29%). Patients exhibited changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the …
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B Raman, MP Cassar, EM Tunnicliffe, N Filippini… - EClinicalMedicine, 2021