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As Deepfake contents continue to proliferate on the internet, advancing face manipulation forensics has become a pressing issue. To combat this emerging threat, previous methods mainly focus on studying how to distinguish authentic and manipulated face images. Despite impressive, image-level classification lacks explainability and is limited to some specific application scenarios. Existing forgery localization methods suffer from imprecise and inconsistent pixel-level annotations. To alleviate these problems, this paper first re-constructs the FaceForensics++ dataset by introducing pixel-level annotations, then builds an extensive benchmark for localizing tampered regions. Next, a novel Multi-Spectral Class Center Network (MSCCNet) is proposed for face manipulation detection and localization. Specifically, inspired by the power of frequency-related forgery traces, we design Multi-Spectral Class Center (MSCC) module to learn more generalizable and semantic-agnostic features. Based on the features of different frequency bands, the MSCC module collects multispectral class centers and computes pixel-to-class relations. Applying multi-spectral class-level representations suppresses the semantic information of the visual concepts, which is insensitive to manipulations. Furthermore, we propose a Multi-level Features Aggregation (MFA) module to employ more low-level forgery artifacts and structure textures. Experimental results quantitatively and qualitatively indicate the effectiveness and superiority of the proposed MSCCNet on comprehensive localization benchmarks. We expect this work to inspire more studies on pixel-level face …