作者
Nikolaj Klöcker, Alessandro Cellerino, Mathias Bähr
发表日期
1998/2/1
期刊
Journal of Neuroscience
卷号
18
期号
3
页码范围
1038-1046
出版商
Society for Neuroscience
简介
Brain-derived neurotrophic factor (BDNF) partially promotes the survival of axotomized retinal ganglion cells (RGCs). In analogy within vitro experiments (; ), we tested whether neuroprotection by BDNF is limited by adverse effects as a consequence of excessive free radical formation. First, we investigated whether BDNF and the free radical scavengerN-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN) cooperate in protecting RGCs from axotomy-induced death. Although systemic S-PBN treatment alone did not influence RGC survival after axotomy, it potentiated the neuroprotective effects of BDNF significantly. Single BDNF treatment rescued 27% of the RGCs, which otherwise would have died 14 d after optic nerve transection, whereas a combined treatment of BDNF and S-PBN improved this rescue rate up to 68%. We then investigated whether the adverse effects of BDNF could be ascribed to activation of nitric oxide …
引用总数
学术搜索中的文章
N Klöcker, A Cellerino, M Bähr - Journal of Neuroscience, 1998