作者
Philip L Tzou, Diane Descamps, Soo-Yon Rhee, Dana N Raugi, Charlotte Charpentier, Nuno Taveira, Robert A Smith, Vicente Soriano, Carmen De Mendoza, Susan P Holmes, Geoffrey S Gottlieb, Robert W Shafer
发表日期
2020/6/11
期刊
The Journal of Infectious Diseases
卷号
221
期号
12
页码范围
1962-1972
出版商
Oxford University Press
简介
Background
HIV-1 and HIV-2 differ in their antiretroviral (ARV) susceptibilities and drug resistance mutations (DRMs).
Methods
We analyzed published HIV-2 pol sequences to identify HIV-2 treatment-selected mutations (TSMs). Mutation prevalences were determined by HIV-2 group and ARV status. Nonpolymorphic mutations were those in <1% of ARV-naive persons. TSMs were those associated with ARV therapy after multiple comparisons adjustment.
Results
We analyzed protease (PR) sequences from 483 PR inhibitor (PI)-naive and 232 PI-treated persons; RT sequences from 333 nucleoside RT inhibitor (NRTI)-naive and 252 NRTI-treated persons; and integrase (IN) sequences from 236 IN inhibitor (INSTI)-naive and 60 INSTI-treated persons. In PR, 12 nonpolymorphic TSMs occurred in ≥11 persons: V33I, K45R, V47A, I50V, I54M, T56V, V62A, A73G …
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PL Tzou, D Descamps, SY Rhee, DN Raugi… - The Journal of Infectious Diseases, 2020