作者
Adam K McDiarmid, David A Broadbent, David M Higgins, Peter P Swoboda, Ananth Kidambi, David P Ripley, Bara Erhayiem, Tarique A Musa, Laura E Dobson, John P Greenwood, Sven Plein
发表日期
2015/8
期刊
Quantitative imaging in medicine and surgery
卷号
5
期号
4
页码范围
503
出版商
AME Publications
简介
Background
Diffuse myocardial fibrosis may be quantified with magnetic resonance (MR) by calculating extracellular volume (ECV) fraction from native and post-contrast T1 values. The ideal modified look-locker inversion recovery (MOLLI) sequence for deriving T1 values has not been determined. This study aims to establish if systematic differences exist between suggested MOLLI schemes.
Methods
Twelve phantom gels were studied with inversion recovery spin echo MR at 3.0 tesla to determine reference T1. Gels were then scanned with six MOLLI sequences (3s) 3b (3s) 5b; 4b (3s) 3b (3s) 2b; 5b (3s) 3b with flip angles of both 35 and 50 at a range of heart rates (HRs). In 10 healthy volunteers MOLLI studies were performed on two separate occasions. Mid ventricular native and post contrast T1 was measured and ECV (%) calculated.
Results
In phantoms, the co-efficient of variability at simulated HR [40-100] with a …
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AK McDiarmid, DA Broadbent, DM Higgins… - Quantitative imaging in medicine and surgery, 2015