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Helically coiled heat exchangers are globally used in various industrial applications for their high heat transfer performance and compact size. Nanofluids can provide excellent thermal performance of this type of heat exchangers. In the present study, the effect of different nanofluids on the heat transfer performance in a helically coiled heat exchanger is examined. Four different types of nanofluids CuO/water, Al₂O₃/water, SiO₂/water, and ZnO/water with volume fractions 1 vol.% to 4 vol.% was used throughout this analysis and volume flow rate was remained constant at 3 LPM. Results show that the heat transfer coefficient is high for higher particle volume concentration of CuO/water, Al₂O₃/water and ZnO/water nanofluids, while the values of the friction factor and pressure drop significantly increase with the increase of nanoparticle volume concentration. On the contrary, low heat transfer coefficient was found in …