作者
Maria Pia Campagna, Eva Kubala Havrdova, Dana Horakova, Guillermo Izquierdo, Fuencisla Matesanz, Sara Eichau, Jeannette Lechner-Scott, Bruce V Taylor, Maria-Isabel García-Sanchéz, Antonio Alcina, Anneke van der Walt, Helmut Butzkueven, Vilija G Jokubaitis
发表日期
2024/3/21
期刊
Multiple Sclerosis Journal
页码范围
13524585241240406
出版商
SAGE Publications
简介
Background
The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity.
Methods
We examined the top variant, rs10191329, from Harroud et al.’s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity.
Results
Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05).
Conclusion
These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.
学术搜索中的文章
MP Campagna, EK Havrdova, D Horakova, G Izquierdo… - Multiple Sclerosis Journal, 2024