作者
Vicki Maltby, Alexandre Xavier, Ewoud Ewing, Maria-Pia Campagna, Sandeep Sampangi, Rodney J Scott, Helmut Butzkueven, Vilija Jokubaitis, Lara Kular, Steffan Bos, Mark Slee, Ingrid A Van Der Mei, Bruce V Taylor, Anne-Louise Ponsonby, Maja Jagodic, Rodney Lea, Jeannette Lechner-Scott
发表日期
2023/8/15
期刊
Neurology
卷号
101
期号
7
页码范围
e679-e689
出版商
Lippincott Williams & Wilkins
简介
Background and Objectives
In multiple sclerosis (MS), accelerated aging of the immune system (immunosenescence) may be associated with disease onset or drive progression. DNA methylation (DNAm) is an epigenetic factor that varies among lymphocyte subtypes, and cell-specific DNAm is associated with MS. DNAm varies across the life span and can be used to accurately estimate biological age acceleration, which has been linked to a range of morbidities. The objective of this study was to test for cell-specific epigenetic age acceleration (EAA) in people with MS.
Methods
This was a case-control study of EAA using existing DNAm data from several independent previously published studies. Data were included if .idat files from Illumina 450K or EPIC arrays were available for both a case with MS and an age-matched and sex-matched control, from the same study. Multifactor statistical modeling was performed to …
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V Maltby, A Xavier, E Ewing, MP Campagna… - Neurology, 2023