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A photonic crystal fiber (PCF)-based plasmonic biosensor for coronavirus detection is analyzed numerically. This can detect COVID spike protein, antibody and the viral ribonucleic acid (RNA) using multi-analyte sensing approach. It is optimized for the specific analytes’ refractive index (RI) range. The sensor shows the average wavelength sensitivities of 2,009 nm/RIU for the protein spike, 1984 nm/RIU for the antibody spike and 2745 nm/RIU for the mutant RNA spike, respectively. The corresponding amplitude sensitivities are 135 RIU-1, 140 RIU-1 and 196 RIU-1. We anticipate the proposed sensor to be a competitive candidate for rapid multi-analyte point-of-care COVID detection.