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Focusing on hybrid nanofluids Cu-AlO and Joule dissipation with bioconvection heat and mass transfer over a nonlinear stretching sheet is the goal of the current work. By applying the appropriate transformations, these equations are converted into ordinary differential equations. The MATLAB-based numerical method “BVP4C” is used to numerically solve the equations. The effects of auxiliary variables on velocity, temperature (T), concentration (C), and gyrotactic microorganisms () are depicted in graphs together with those of Prandtl number, bioconvection Rayleigh number, couple stress parameter, Schmidt number, and Bioconvection Schmidt number.