作者
Nilesh J Samani, Jeanette Erdmann, Alistair S Hall, Christian Hengstenberg, Massimo Mangino, Bjoern Mayer, Richard J Dixon, Thomas Meitinger, Peter Braund, H-Erich Wichmann, Jennifer H Barrett, Inke R König, Suzanne E Stevens, Silke Szymczak, David-Alexandre Tregouet, Mark M Iles, Friedrich Pahlke, Helen Pollard, Wolfgang Lieb, Francois Cambien, Marcus Fischer, Willem Ouwehand, Stefan Blankenberg, Anthony J Balmforth, Andrea Baessler, Stephen G Ball, Tim M Strom, Ingrid Brænne, Christian Gieger, Panos Deloukas, Martin D Tobin, Andreas Ziegler, John R Thompson, Heribert Schunkert
发表日期
2007/8/2
期刊
New England Journal of Medicine
卷号
357
期号
5
页码范围
443-453
出版商
Massachusetts Medical Society
简介
Background
Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease.
Methods
We first identified chromosomal loci that were strongly associated with coronary artery disease in the Wellcome Trust Case Control Consortium (WTCCC) study (which involved 1926 case subjects with coronary artery disease and 2938 controls) and looked for replication in the German MI [Myocardial Infarction] Family Study (which involved 875 case subjects with myocardial infarction and 1644 controls). Data on other single-nucleotide polymorphisms (SNPs) that were significantly associated with coronary artery disease in either study (P<0.001) were then combined to identify additional loci with a high probability of true association. Genotyping in both studies was performed with the use of …
引用总数
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NJ Samani, J Erdmann, AS Hall, C Hengstenberg… - New England Journal of Medicine, 2007