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In this paper, taking the vegetation in Karst rocky area as the research subject, MODIS enhanced vegetation index (EVI) series and climatic information during 2001-2010 are used to analyze the relationship between vegetation and climate factors. Vapor pressure, precipitation, relative humidity, maximum temperature, minimum temperature, mean temperature, dew point temperature, wind speed and sunshine hours are taken as climatic variables to explore their relationships with EVI series in different stages using correlation analysis method and path analysis method. Then, climatic factors are selected to establish EVI simulation models of Karst vegetation by stepwise regression analysis method. The results show that: There are significant positive correlations between EVI of Karst vegetation and most climatic factors. The correlation coefficients between EVI and the climatic factors including vapor pressure, mean …