作者
Giovanni Sotgiu, Rosella Centis, Lia D'Ambrosio, Jan-William C Alffenaar, Holly A Anger, Jose A Caminero, Paolo Castiglia, Saverio De Lorenzo, Giovanni Ferrara, Won-Jung Koh, Giesela F Schecter, Tae S Shim, Rupak Singla, Alena Skrahina, Antonio Spanevello, Zarir F Udwadia, Miquel Villar, Elisabetta Zampogna, Jean-Pierre Zellweger, Alimuddin Zumla, Giovanni Battista Migliori
发表日期
2012/12/1
来源
European Respiratory Journal
卷号
40
期号
6
页码范围
1430-1442
出版商
European Respiratory Society
简介
Linezolid is used off-label to treat multidrug-resistant tuberculosis (MDR-TB) in absence of systematic evidence. We performed a systematic review and meta-analysis on efficacy, safety and tolerability of linezolid-containing regimes based on individual data analysis.
12 studies (11 countries from three continents) reporting complete information on safety, tolerability, efficacy of linezolid-containing regimes in treating MDR-TB cases were identified based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Meta-analysis was performed using the individual data of 121 patients with a definite treatment outcome (cure, completion, death or failure).
Most MDR-TB cases achieved sputum smear (86 (92.5%) out of 93) and culture (100 (93.5%) out of 107) conversion after treatment with individualised regimens containing linezolid (median (inter-quartile range) times for smear and culture …
学术搜索中的文章
G Sotgiu, R Centis, L D'Ambrosio, JWC Alffenaar… - European Respiratory Journal, 2012