作者
R Diel, D Goletti, Giovanni Ferrara, G Bothamley, D Cirillo, B Kampmann, C Lange, M Losi, R Markova, GB Migliori, A Nienhaus, M Ruhwald, D Wagner, JP Zellweger, E Huitric, A Sandgren, D Manissero
发表日期
2011/1/1
来源
European Respiratory Journal
卷号
37
期号
1
页码范围
88-99
出版商
European Respiratory Society
简介
We conducted a systematic review and meta-analysis to compare the accuracy of the QuantiFERON-TB® Gold In-Tube (QFT-G-IT) and the T-SPOT®.TB assays with the tuberculin skin test (TST) for the diagnosis of latent Mycobacterium tuberculosis infection (LTBI).
The Medline, Embase and Cochrane databases were explored for relevant articles in November 2009. Specificities, and negative (NPV) and positive (PPV) predictive values of interferon-γ release assays (IGRAs) and the TST, and the exposure gradient influences on test results among bacille Calmette–Guérin (BCG) vaccinees were evaluated.
Specificity of IGRAs varied 98–100%. In immunocompetent adults, NPV for progression to tuberculosis within 2 yrs were 97.8% for T-SPOT®.TB and 99.8% for QFT-G-IT. When test performance of an immunodiagnostic test was not restricted to prior positivity of another test, progression rates to tuberculosis among …
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R Diel, D Goletti, G Ferrara, G Bothamley, D Cirillo… - European Respiratory Journal, 2011