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Centenarians are rare and exceptional individuals characterized by a peculiar phenotype. They are the best example of healthy aging in humans as most of them have escaped or substantially delayed the onset of major age-related diseases. Within this scenario, the purpose of the present work was to understand if immune status is associated with survival and health status in centenarians. To this aim, 116 centenarians were concomitantly characterized for their immunological, health and functional status, and followed-up for five-year survival. On the basis of previous knowledge we focused on a core of fundamental and basic immune parameters (number of leukocytes, monocytes, total lymphocytes, CD3⁺ T lymphocytes, CD4⁺ helper T lymphocytes, CD8⁺ cytotoxic T lymphocytes, CD19⁺ B lymphocytes and plasma levels of IgM), and the most important findings can be summarized as follows: i. a hierarchical …