作者
Tara L Moore, Ronald J Killiany, Monica A Pessina, Mark B Moss, Seth P Finklestein, Douglas L Rosene
发表日期
2012/3/1
期刊
Neurobiology of aging
卷号
33
期号
3
页码范围
619. e9-619. e24
出版商
Elsevier
简介
Studies of recovery from stroke mainly utilize rodent models and focus primarily on young subjects despite the increased prevalence of stroke with age and the fact that recovery of function is more limited in the aged brain. In the present study, a nonhuman primate model of cortical ischemia was developed to allow the comparison of impairments in young and middle-aged monkeys. Animals were pretrained on a fine motor task of the hand and digits and then underwent a surgical procedure to map and lesion the hand-digit representation in the dominant motor cortex. Animals were retested until performance returned to preoperative levels. To assess the recovery of grasp patterns, performance was videotaped and rated using a scale adapted from human occupational therapy. Results demonstrated that the impaired hand recovers to baseline in young animals in 65–80 days and in middle-aged animals in 130–150 …
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TL Moore, RJ Killiany, MA Pessina, MB Moss… - Neurobiology of aging, 2012