作者
TL Moore, BGE Bowley, MA Pessina, SM Calderazzo, M Medalla, V Go, ZG Zhang, Michael Chopp, S Finklestein, AG Harbaugh, DL Rosene, Benjamin Buller
发表日期
2019/1/1
期刊
Restorative neurology and neuroscience
卷号
37
期号
4
页码范围
347-362
出版商
IOS Press
简介
Background: Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke.
Objective: Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury. Methods: After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury, monkeys received exosomes or vehicle control. Recovery of motor function was followed for 12 weeks. Results: Compared to monkeys that received vehicle, exosome treated monkeys returned to pre-operative grasp patterns and latency to retrieve a food reward in the first three-five weeks of recovery. Conclusions: These results provide evidence that in monkeys exosomes delivered after cortical injury enhance recovery of …
学术搜索中的文章
Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury
TL Moore, BGE Bowley, MA Pessina, SM Calderazzo… - Restorative neurology and neuroscience, 2019