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The high level of complexity of supply chains and the inherent risks that exist in both the demand and supply of resources – especially in economic downturns – are recognized as major limiting factors in achieving high levels of supply chain performance. The use of modern information technology (IT) decision support systems is fast becoming an indispensable tool for designing and managing complex supply chain systems today. This paper develops a framework for the design of a multi-agent based decision support system for the management disruptions and mitigation of risks in manufacturing supply chains.