查看文章

Identifying essential genes and proteins is a critical step towards a better understanding of human biology and pathology. Computational approaches helped to mitigate experimental constraints by exploring machine learning (ML) methods and the correlation of essentiality with biological information, especially protein-protein interaction (PPI) networks, to predict essential genes. Nonetheless, their performance is still limited, as network-based centralities are not exclusive proxies of essentiality, and traditional ML methods are unable to learn from non-euclidean domains such as graphs. Given these limitations, we proposed EPGAT, an approach for Essentiality Prediction based on Graph Attention Networks (GATs), which are attention-based Graph Neural Networks (GNNs), operating on graph-structured data. Our model directly learns gene essentiality patterns from PPI networks, integrating additional evidence from …