查看文章

Background: Morin is natural flavonoids obtained from Moraceae family, found to be associated with many therapeutic properties like anti-inflammatory, anti-cancer and cardio-protective activities.

Aim: The aim of present study is to synthesise flavone (JPG-I), a derivative of Morin (JPG-II) by simple acetylation and to investigate their comparative hepatoprotective activity with Morin.

Methods: Standard (Silymarin 100 mg/kg), morin (40 mg/kg), JPG-I (40 mg/kg), JPG-II (40 mg/kg), were administered per orally for 21 days in 40% alcohol (2 ml/100 g/day, po) treated groups. Body weight and urine analysis were assessed on 7th, 14th, and 21st day. On 21st day animals were sacrificed and blood was collected for assessment of liver profile (SGOT, SGPT, ALP, TB) and liver was isolated to carry out the evaluation of biochemical (LPO, GSH, nitrate).

Results: The present study demonstrated that there was decrease in body weight, increase in liver function enzymes (SGOT, SGPT, ALP, TB) and oxidative stress parameter level in alcohol treated group on 7th, 14th, and 21st day. Whereas reverse was observed with test compounds (morin, JPG-I and JPG-II).

Conclusion: Compound JPG-II treated group was found to be more effective as compared to morin and JPGI treated group.